• Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 1, Issue 6 (2013)

Molecular Target-Oriented Phytochemical Database and Its Application to the Network Analysis of Action Mechanisms of Herbal Medicines

Author(s):

Hitoshi Kojo, Yukihiro Eguchi, Toshikazu Miyagishima, Kimiko Makino and Hiroshi Terada

Abstract:
Kampo medicines, the Japanese adaptation of traditional Chinese medicines, are formed by combining several herbs containing multiple phytochemicals. The considerable ambiguity of pharmacological profiles of Kampo medicines is expected to be clarified by identifying the molecular targets of constituent phytochemicals and analyzing the combined effects of the phytochemicals on the pharmacological pathways formed by those targets. To facilitate this line of study, we constructed paired databases named PhytodamaTarget and PhytodamaTaxon DBs which treat molecular targets of phytochemicals and constituent phytochemicals of plant taxa, respectively, by utilizing information from the literature. We then used the databases to explore possible mechanisms of synergism in analgesic activity between Glycyrrhiza globra and Paeonia lactiflora.

Pages: 19-26  |  1573 Views  39 Downloads

How to cite this article:
Hitoshi Kojo, Yukihiro Eguchi, Toshikazu Miyagishima, Kimiko Makino and Hiroshi Terada. Molecular Target-Oriented Phytochemical Database and Its Application to the Network Analysis of Action Mechanisms of Herbal Medicines. J Pharmacogn Phytochem 2013;1(6):19-26.