Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 1 (2013)
Phytochemical properties, total antioxidant status of acetone and methanol extract of Terminalia arjuna Roxb. bark and its hypoglycemic effect on Type-II diabetic albino rats.
Chandan Kumar*, Raj Kumar, Shamshun Nehar
In the present study, acetone and methanol extract of T. arjuna Roxb. bark was evaluated for its phytochemical properties and antioxidant status by FRAP method. The result indicated that tannin, alkaloid, triterpenoid, flavonoid, phytosteroids and saponin are present in both the acetone and methanol extract. Total antioxidant status was found to be significantly (PË‚0.01) higher in acetone extract (212.5Â±11.55 ÂµM) as compared to methanol extract (35.50Â±4.70 ÂµM). This indicates higher antioxidative property of T. arjuna bark acetone extract in comparison to methanol extract and selected for in vivo study. In vivo study, showed protective effect of acetone extract of T. arjuna bark towards blood glucose, oral glucose tolerance (OGTT) and insulin tolarence test in STZ treated rats. Feeding 500 mg/kg bw arjuna bark extract to rats showed significantly (P<0.05) lower parameters as compared to rats of diabetic control rats and 250 mg/kg bw arjuna bark fed rats and was non-significant with glimepiride fed rats. Feeding 500 mg/kg bw extract showed significantly (P<0.05) higher anti-hyperglycemic and anti-diabetic effects as compared to 250 mg/kg bw extract. It is concluded that the acetone extract of Terminalia arjuna bark exhibit antioxidant power and hypoglycemic properties.
Pages: 199-208 | 1361 Views 19 Downloads
Chandan Kumar*, Raj Kumar, Shamshun Nehar. Phytochemical properties, total antioxidant status of acetone and methanol extract of Terminalia arjuna Roxb. bark and its hypoglycemic effect on Type-II diabetic albino rats.. J Pharmacogn Phytochem 2013;2(1):199-208.