Journal of Pharmacognosy and Phytochemistry
Vol. 4, Issue 1 (2015)
Anti-diabetic activity of Ipomoea quamoclit in Streptozotocin Induced diabetic rats
Raveendra Reddy J, Sanjeeva Kumar A, Rama Mohan Gupta V
Present study was undertaken to screen the antidiabetic activity of Ipomoea quamoclit whole plant belongs to Convolvulaceae family. Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of whole plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1st, 10th, 20th and 30th day of study. Lipid profile was studied 30th day of study and body weight of the animals was measured at day 1 and 30. Thirty days administration of hydroalcoholic extract of Ipomoea quamoclit whole plant showed a significant (p<0.001) reduction in blood glucose levels at both dose levels under study that is 250 and 500 mg/kg body weight in comparison with diabetic control group. Standard drug also exhibited a significant (p<0.001) reduction in blood glucose levels of the animals in comparison with diabetic control. In biochemical parameters, significant (p<0.05) effect on triglycerides at its lower dose, significant (p<0.05) on total cholesterol levels and HDL, LDL and VLDL levels and also significant (p<0.01 and p<0.001) at its high dose that is 500 mg/kg body weight and a good control (p<0.01) over the body weight of the animals in comparison with diabetic control group. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.
Pages: 68-71 | 1525 Views 67 Downloads
Raveendra Reddy J, Sanjeeva Kumar A, Rama Mohan Gupta V. Anti-diabetic activity of Ipomoea quamoclit in Streptozotocin Induced diabetic rats. J Pharmacogn Phytochem 2015;4(1):68-71.