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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 6, Issue 3 (2017)

Screening of isolated phytosterol from leaves of Holoptelea integrifolia (Roxb.) Planch for it’s anticonvulsant activity in experimental animals

Author(s):

Sudhir Singh Gangwar, Amita Tilak, Ranjana Sharma, RN Thakur and Ravindra C Sutar

Abstract:
Objective: The majority of scientific documentation suggested prominent role of Phytosterols towards anticonvulsant activity. The main objective of the work was to evaluate anticonvu ant activity of Holoptelea integrifolia isolated Phytosterol (HIIP) from petroleum ether extract (PEHI) of leaves of Holoptelea integrifolia (Roxb) Planch
Methods: The anticonvulsant activity of different doses of HIIP (10 and 30 mg/kg-p.o.) was evaluated using Pentylenetetrazole (PTZ) induced convulsions in mice and lithium-pilocarpine induced status epilepticus in rats.
Results: HIIP 30 mg/kg was more potent than HIIP 10 mg/kg for showing anticonvulsant activity.
Conclusions: The results indicate that HIIP shows anticonvulsant activity which was dose dependent.

Pages: 657-661  |  719 Views  18 Downloads

How to cite this article:
Sudhir Singh Gangwar, Amita Tilak, Ranjana Sharma, RN Thakur and Ravindra C Sutar. Screening of isolated phytosterol from leaves of Holoptelea integrifolia (Roxb.) Planch for it’s anticonvulsant activity in experimental animals. J Pharmacogn Phytochem 2017;6(3):657-661.