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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 6, Issue 4 (2017)

Antioxidant activity of ethanolic extract of Alpinia calcarata Rosc. Rhizome

Author(s):

Majidul Islam, Rumana Yesmin, Hanif Ali, Polash Chandra Karmakar, Ayshasiddeka, Farjana Islam, M Rowshanul Habib and Tanzima Yeasmin

Abstract:
Alpinia calcarata belonging to the family of Zingiberaceae is commonly found in Bangladesh and has been conventionally used in medicine systems for the prevention of many diseased conditions. The present study was conducted to explore the antioxidant activity of ethanolic extract of Alpinia calcarata rhizome (EEACR). EEACR was studied for the quantitative estimation of phenolic, flavonoid, proanthocyanidin and flavonol compounds. Antioxidant activity was evaluated by using several in vitro standard methods. EEACR was subjected to GC-MS analysis to identify its phytoconstituents. EEACR contained a good amount of phenol, flavonoid, proanthocyanidin and flavonol. The IC50 value of the ethanol extract in the DPPH, ABTS, nitric oxide, lipid peroxidation inhibition and ferrous chelating assay were 6.044, 5.266, 25.13, 21.88, and 63.33µg/ml, respectively. EACR also showed remarkable ferric reducing and total antioxidant capacity. The total phenolic and flavonoid contents of EEACR were positively correlated (p<0.05) with DPPH, ABTS, nitric oxide, lipid peroxidation inhibition and ferrous chelating assay. In addition, the active compound present in the ethanol extract was identified as α-asarone by GC-MS analysis. In summary, our results suggest that ethanol extract of Alpinia calcarata rhizome possess a wide range of pharmacologically important phytochemicals which exhibited strong antioxidant activity.

Pages: 469-474  |  906 Views  64 Downloads

How to cite this article:
Majidul Islam, Rumana Yesmin, Hanif Ali, Polash Chandra Karmakar, Ayshasiddeka, Farjana Islam, M Rowshanul Habib and Tanzima Yeasmin. Antioxidant activity of ethanolic extract of Alpinia calcarata Rosc. Rhizome. J Pharmacogn Phytochem 2017;6(4):469-474.