Journal of Pharmacognosy and Phytochemistry
Vol. 7, Issue 5 (2018)
Antioxidant and anti-AGEs (Advanced glycation end-product) activities of ethanolic extract of Ficus carica Linn from Indonesia
Syamsudin Abdillah and Abdi Wibowo Prakoso
Background and Objective:
The tin leaf contains flavonoid and phenol compounds, which are known to act as antioxidants. The objective of this study was to investigate the antioxidant activity and inhibition of Advanced Glycation End-Products (AGEs) from 96% tin ethanol extract (Ficus carica
L.) based on the inadequacy of DPPH and AGEs compound levels formed.
Materials and Methods: Different concentrations of tin leaf extract were tested with a radical compound of DPPH, with Vitamin C as a positive control. The inhibitory activity of AGEs compound formation was studied by reacting high concentrated sugar solution with protein in the form of Bovine Serum Albumin. With quercetin used as a positive control for barrier testing on the formation of AGEs. The reaction of tin leaf extract was determined by measuring the total content of the phenol compound using Folin-Ciocalteu reagent.
Results: The results showed that 96% of ethanol extract had a potent antioxidant activity, buthad little ability to inhibit AGEs. With IC50 values of 55.38 μg/ml as an antioxidant and 750.29 μg/ml inhibiting AGEs, total phenol content of tin leaf extract was 0.71%.
Conclusion: Based on this information, it can be concluded that the 96% ethanol extract of tin leaf has a strong and an antioxidant activity. However it is in inhibiting AGEs compounds.
Pages: 598-601 | 826 Views 129 Downloads
Syamsudin Abdillah and Abdi Wibowo Prakoso. Antioxidant and anti-AGEs (Advanced glycation end-product) activities of ethanolic extract of Ficus carica Linn from Indonesia. J Pharmacogn Phytochem 2018;7(5):598-601.