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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 8, Issue 6 (2019)

Effect on the body weight, organ weight and haematology during sub-chronic lantadene toxicity and its amelioration with Berberis lycium and Picrorhiza kurroa in guinea pigs

Author(s):

Punam Soren, Rinku Sharma, Manish Kharwal, Rahul Singh, Birbal Singh and Gorakh Mal

Abstract:
Background: The objective of this study was to investigate the ameliorative effect of Berberis lycium and Picrorhiza kurroa on lantadene-induced sub-chronic toxicity in Guinea pigs.
Method: Total 42 Guinea pigs of either sex were divided into 7 groups: Group-C served as control, Group- L (Lantadene @ 24mg/kg bw), Group-L+B1 (B. lycium @ 100 mg/kg bw), Group- L+B2 (B. lycium @ 200 mg/kg bw), Group- L+P1 (P. kurroa @ 100 mg/kg bw), Group- L+P2 (P. kurroa @ 200 mg/kg bw), Group- L+ S (Silymarin @ 100 mg/kg bw). Each group except control received oral dose of lantadene (24 mg/kg bw) daily. Ameliorative groups were treated with daily oral dose of ameliorative plant extract one hour after lantadene treatment.
Results: Significant decrease in weekly body weights, Hb (gm/dl), PCV% and significant increase in absolute and relative weight of liver were recorded.

Pages: 373-377  |  1000 Views  298 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Punam Soren, Rinku Sharma, Manish Kharwal, Rahul Singh, Birbal Singh and Gorakh Mal. Effect on the body weight, organ weight and haematology during sub-chronic lantadene toxicity and its amelioration with Berberis lycium and Picrorhiza kurroa in guinea pigs. J Pharmacogn Phytochem 2019;8(6):373-377.

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