Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 7, Special Issue 6 (2018)

Development, evaluation and optimization of smoking cessation patch containing antidepressant drugs

Author(s): Pravin Jagtap and RD Wagh
Abstract: Selegiline HCl and Nicotine has short half-life in the body due to first-pass metabolism. Hence, it required frequent dosing. Transdermal patch of Selegiline HCl and Nicotine was prepared to sustain the release and improve bioavailability of drug and patient compliance. Different formulations were prepared by varying the grades of Ethyl Cellulose and concentration of PVP by solvent casting method. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, and drug excipient compatibility. A 32 full factorial design was applied to check the effect of varying the grades of Ethyl Cellulose (𝑋1) and PVP concentration (𝑋2) on the responses, that is, tensile strength, percentage drug released and diffusion coefficient as a dependent variables. In vitro release data were fitted to various models to ascertain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The results of the F2 statistics between factorial design batches and theoretical profile were used to select optimized batch. Batch F6 was considered optimum batch which contained Ethyl Cellulose and PVP (1:1), showed satisfactory release, and was more similar to the theoretical predicted dissolution profile.
Pages: 42-47  |  705 Views  19 Downloads
How to cite this article:
Pravin Jagtap and RD Wagh. Development, evaluation and optimization of smoking cessation patch containing antidepressant drugs. 2018; 7(6S): 42-47. DOI: 10.22271/phyto.2018.v7.isp6.1.11
Journal of Pharmacognosy and Phytochemistry