Matrix metalloproteinase’s in atheroma formation in arteriosclerotic vascular disease
Author(s): Juvatkar PV, Bhagyalakshmi Nair, Mayuri Patil, Kale MK, Akshaya G and Priyanka K
Abstract: Matrix metalloproteinase’s (MMPs) which are also called as matrixins belongs to a group of zinc-dependent proteins (endopeptidases), which play a vital part in the depletion of extracellular matrix. This group of enzymes consists of expanded spectrum of proteases type of enzyme (like collagenases, stromelysins, and gelatinases) which plays an influential and conspicuous role in tissue reformation and remodeling mechanism which is associated with different cascades of processes like morphogenesis, angiogenesis, arthritis, cancer etc. Atherosclerosis is a pathological condition were the innermost layers of the arteries becomes thick due to the accumulation of WBC’s (like macrophages, foam cells) and also due to the rapid multiplication of cells present in the intimate layers of artery that creates a plaque. Studying the role and importance of MMP’S in plaque formation has now become an important field of interest. Excessive tissue alteration process and increased activities of matrix metalloproteinase enzyme have been authenticated in plaque interruption. These enzymes represent a fundamental target for the therapeutic innovations in vascular pathology.
Juvatkar PV, Bhagyalakshmi Nair, Mayuri Patil, Kale MK, Akshaya G and Priyanka K. Matrix metalloproteinase’s in atheroma formation in arteriosclerotic vascular disease. 2018; 7(6S): 56-60. DOI: 10.22271/phyto.2018.v7.isp6.1.13
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