Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Login

NAAS Rating: 5.21

updates
NAAS Rating: 5.21 new

Journal of Pharmacognosy and Phytochemistry

Vol. 2, Issue 5 (2014)

Sedative, anxiolytic and antidepressant-like effects of inhalation of the essential oil of Ocimum gratissimum L. from cameroon in mice

Author(s): Joan Manjuh Tankam, Michiho Ito
Abstract: In this study, the behavioral effects of inhalation of the essential oil of Ocimum gratissimum from Cameroon were investigated. The open field test, light/dark box test, tail suspension test and Rota-rod test were used to assess the sedative, anxiolytic-like, antidepressant-like and motor coordination effects respectively, in mice. GC and GC/MS analyses were performed to investigate the chemical composition of O. gratissimum essential oil. Phytochemical analysis revealed thymol (68%) as main compound of O. gratissimum essential oil. Inhalation of O. gratissimum essential oil showed potent sedative, anxiolytic and antidepressant-like effects in mice, and did not cause any deleterious effects on motor coordination. It is suggested that a synergistic effect of the constituents of O. gratissimum essential oil might account for its sedative activity. In conclusion, inhalation of O. gratissimum essential oil might have aromatherapeutic potential.
 Effects of thymol on mouse locomotor activity. Total spontaneous locomotor activity of mice treated with vehicle (triethyl citrate 400 µL; Cont.) and thymol. Data are shown as the mean ± standard error of the mean of 6 mice. Statistical differences vs. the control group were calculated using analysis of the variance followed by Dunnett’s test.*p<0.05, **p<0.01.
Fig.: Effects of thymol on mouse locomotor activity. Total spontaneous locomotor activity of mice treated with vehicle (triethyl citrate 400 µL; Cont.) and thymol. Data are shown as the mean ± standard error of the mean of 6 mice. Statistical differences vs. the control group were calculated using analysis of the variance followed by Dunnett’s test.*p<0.05, **p<0.01.
Pages: 01-09  |  1321 Views  22 Downloads
How to cite this article:
Joan Manjuh Tankam, Michiho Ito. Sedative, anxiolytic and antidepressant-like effects of inhalation of the essential oil of Ocimum gratissimum L. from cameroon in mice. Journal of Pharmacognosy and Phytochemistry. 2014; 2(5): 01-09.
Call for book chapter
Journals List Click Here Research Journals Research Journals
Journal of Pharmacognosy and Phytochemistry