Author(s):

Farhana Alam Ripa, Pritesh Ranjan Dash and Md. Omar Faruk

Abstract: This study was aimed to investigate CNS depressant, analgesic and anti-inflammatory activities of methanolic seed extract of Calamus rotang (MCRS)in rats. Hole cross and open field tests for CNS depressant effect, acetic acid-induced writhing and formalin induced pain methods for analgesic and carrageenan-induced paw edema was performed to evaluate anti-inflammatory effect of the doses of 250 and 500 mg/kg b.w. respectively. In hole cross and open field tests, maximum suppression of locomotor activity were 81.42% and 86.61% with the higher dose (500 mg/kg) of extract, whereas for the standard drug diazepam (1 mg/kg) inhibition rate were 87.14% and 91.86% respectively. MCRS at the dose of 500 mg/kg exhibited maximum 51.27% inhibition against acetic acid-induced pain while indomethacin (10 mg/kg) displayed 58.86% inhibition. In formalin-induced test, 68.47% inhibition was produced by MCRS (500 mg/kg) and indomethacin produced 70.72% inhibition. In anti-inflammatory activity, the extract showed a significant (p<0.01) inhibition of paw edema after 30 min to 240 min compare to indomethacin. MCRS significantly (P<0.01) showed the above mentioned pharmacological effects in a dose dependent manner.

Pages: 121-125  |  2442 Views  407 Downloads

Download (369KB)