Pharmacognosy

Journal of Pharmacognosy and Phytochemistry

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Journal of Pharmacognosy and Phytochemistry

Vol. 4, Issue 2 (2015)

Thrombolytic and membrane stabilizing activities of ethanolic extract of local medicinal plant Murraya paniculata. (Family:Rutaceae)

Author(s): Farhina Rahman Laboni, Faria Afsari, Md. Sariful Islam Howlader, Zubair Khalid Labu, Azima Sultana Julie
Abstract: Murraya paniculata (M. paniculata), has a history of ethnomedicinal properties. The crude ethanolic extract and its different partitionates of the leaves of M. paniculata was evaluated for its possible thrombolytic and membrane stabilizing activity. The activities of leaf extract were evaluated by using different drugs; Streptokinase (SK) was used as standard drug for thrombolytic activity, and acetyl salicylic acid (ASA) as standard drug for membrane stabilizing activity. In this study, standard drug SK showed 65% against thrombosis, the ethanolic soluble fraction of leaves (ESF) 43.28%, n-Hexane soluble fraction (HXSF) 58.06%, whereas chloroform soluble fraction (CSF) 27.66% and aqueous soluble fraction (AQSF) 22.81%, and for against unstable membrane, standard drug ASA exhibited 71.90±29% inhibition of haemolysis of human red blood cell (RBC) membrane in normal conditions, whereas 62.12±0.26% in heat induced conditions. In normal conditions the AQSF inhibited 33.49±0.51%, ESF inhibited 40.23±0.64%, CSF inhibited 42.66±0.77% and HXSF 60.35±0.50% while in heat induced conditions AQSF inhibited 30.34± 0.42%, ESF inhibited 41.53±0.61%, CSF inhibited 36.22±0.57%, HXSF inhibited 44.11±0.69% respectively. Hence, the results of the present study revealed that the traditional uses of this plant leaves is a remedy for thrombosis and unstable lysosomal membrane.
Pages: 17-20  |  1334 Views  19 Downloads
How to cite this article:
Farhina Rahman Laboni, Faria Afsari, Md. Sariful Islam Howlader, Zubair Khalid Labu, Azima Sultana Julie. Thrombolytic and membrane stabilizing activities of ethanolic extract of local medicinal plant Murraya paniculata. (Family:Rutaceae). 2015; 4(2): 17-20.
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