Author(s):

Md. Abdullah Aziz, Kishore Kumar Sarkar, Mst. Irin Akter, AK Lutful Kabir and Debendra Nath Roy

Abstract: In the present study the methanolic extract of Borassus flabellifer L. (MBF) was evaluated for the safety along with neuropharmacological activity by using OECD guidelines, y-maze, elevated plus-maze and open field test respectively. Mortality, sign of any toxicity or behavioral changes were not noticed up to the dose as high as 4000mg/kg. Moreover, in y-maze test, MBF 200 mg/kg and MBF 400 mg/kg exhibited anti-depressive and depressive activities. Again, every extract including both lower and higher doses elicited depressive, anti- depressive and anxiolytic activities in elevated plus maze test. Later, in open field test, significant (p<0.05, vs.control) CNS depressive activities were found by both MBF 200 mg/kg and MBF 400 mg/kg. The results obtained in the present study demonstrated that MBF can be the possible sources of CNS depressant, anti- depressant and anxiolytic agents. But further investigation is needed for the identification of the active compounds as well as confirmation of their activities.

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