Author(s):

Pragati Patel, Aditya Mishra, Amir Amin Sheikh, Kailash Kumar, Rakshanda Bhagat and Uttarani Maibam

Abstract: Adrenomedullin is a peptide hormone extracted from pheochromocytoma in humans has 52 amino acid held together by a single disulphide bond. The name adrenomedullin was given as it is abundantly found in adrenal medulla, comes under calcitonin gene-related peptide family. Production of adrenomedullin is up-regulated by several factors such as oxidative stress, pro-inflammatory cytokines, angiotensin II, hypoxia, hyperglycemia, natriuretic peptide and aldosterone. It is synthesized as part of a larger precursor molecule, termed preproadrenomedullin. Adrenomedullin receptor consists of seven transmembrane domains and belongs to G-protein dependent receptor family. This peptide has not only a potent hypotensive and vasorelaxing effect but it performs various biological functions. It has potent effects on cell migration, growth, and apoptosis. So with this overview adrenomedullin is a novel peptide hormone that plays significant physiological functions in different systems of the body.

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