Author(s):

Atul Sohgaura, Papiya Bigoniya and Birendra Shrivastava

Abstract: The study aims at enrichment of C. dactylon, E. officinalis, K. pinnata and B. nutans ethyl acetate fractions with its acute toxicity and diuretic potential exploration. Ethyl acetate fractions was separated from hydro-methanolic extract of C. dactylon, E. officinalis, K. pinnata and B. nutans. Acute toxicity was determined as per the guidelines of organization for Economic Co-operation and Development (OECD) guideline No. 423 and 420 followed by diuretic potential assessment by Lipschitz test. Acute toxicity limit test showed the LD₅₀ to be greater than the test dose 2000 mg/kg for C. dactylon, K. pinnata and B. nutans, and 1000 mg/kg for E. officinalis ethyl acetate fractions. C. dactylon, E. officinalis, K. pinnata and B. nutans has showed high sodium (Na⁺) and potassium (K⁺) excretion potential where as high chloride (Cl⁻) excretion ability was observed in K. pinnata followed by C. dactylon and E. officinalis. Most potential diuretic activity was observed in K. pinnata and C. dactylon ethyl acetate fraction that can be correlated to rich presence of flavonoids and polyphenols. The present study supports the traditional and Ayurvedic use of K. pinnata, C. dactylon and E. officinalis plants for diuretic potential.

Pages: 2895-2900  |  1170 Views  368 Downloads

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