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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 1, Issue 4 (2012)

Isolation of Crotepoxide From Berries of Croton Macrostachyus and Evaluation of Its Anti-Leishmanial Activity

Author(s):

Habtamu Gelaw, Legesse Adane*, Yinebeb Tariku, Asrat Hailu

Abstract:
The chloroform extract of the berries of Croton macrostachyus was subjected to column chromatography with chloroform: ethyl acetate mixture as eluting solvent that led to isolation of Crotepoxide. Evaluation of antleishmanial activity of crotepoxide against promatigotes and amastigotes form of L. aethiopica showed that the compound is less active as compared to the reference antileishamnial drugs (amphotericin B and miltefosine). Regardless of the observed activity, further in vivo tests are recommended before drawing any conclusion about the potential of the compound as a new antileishamnial drug candidate.

Pages: 15-24  |  2701 Views  452 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Habtamu Gelaw, Legesse Adane*, Yinebeb Tariku, Asrat Hailu. Isolation of Crotepoxide From Berries of Croton Macrostachyus and Evaluation of Its Anti-Leishmanial Activity. J Pharmacogn Phytochem 2012;1(4):15-24.

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