Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 1 (2013)
Evaluation of Antidiabetic Activity of Methanolic Extracts from the Aerial Parts of Barleria Montana in Streptozotocin Induced Diabetic Rats
Shyam T* , Ganapaty S
Based on ethnopharmacological information, Barleria montana has been used to treat diabetes by the tribals in and around tropical and subtropical areas.But there are no more scientific reports available about the antidiabetic activity of this plant. Hence the study was carried out to ascertain the activity.The plant was extracted with methanol in soxhlet apparatus and the extracts thus obtained were examined for acute toxicity studies in wistar albino rats at different doses upto 2000 mg/kg body weight. The plant extracts were also evaluated for antidiabetic activity at a dose levels of 100,200 and 400 mg/kg in streptozotocin induced diabetic rats.The plant extracts have not produced any toxic symptoms within the treated animals. The maximum reduction in blood glucose level was observed at 8 and 12th hr. after the oral administration of the 400 and 200 mg/kg b. w of methanolic extract of Barleria montana aerial parts respectively. From the observations, it was concluded that the reduction of blood glucose levels in diabetic rats was found to be dose dependent and also dependent on duration of action. So it might be useful in the treatment of diabetes without toxicity.
Pages: 187-192 | 2211 Views 214 Downloads
Shyam T* , Ganapaty S. Evaluation of Antidiabetic Activity of Methanolic Extracts from the Aerial Parts of Barleria Montana in Streptozotocin Induced Diabetic Rats. J Pharmacogn Phytochem 2013;2(1):187-192.