Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 1 (2013)
In-Vitro Cytotoxic and Thrombolytic Potential of Pothos Scandens L
A.T.M Yusuf, Mohammad Mamun Ur Rashid*, Mohammed Mainul Hassan, Mohammed Aktar Sayeed, Mohammed Abdullah Jainul
The methanolic extract of leaf of Pothos scandens was subjected to screening for cytotoxic activity by in-vitro brine shrimp lethality bioassay and thrombolytic activity. In brine shrimp bioassay, the crude methanolic extract of leaf showed strong cytotoxic activity with LC50 value of 14.195Î¼g/ml compared to that of 0.305Î¼g/ml exhibited by standard vincristine sulphate. During assay for thrombolytic activity, the methanolic extract of P. scandens revealed 19.451Â±1.711% lysis of clot while standard streptokinase (SK) and water, used as positive and negative controls, demonstrated 69.480Â± 2.651% and 3.0695Â± 0.497% lysis of clot, respectively.
Pages: 193-198 | 2332 Views 238 Downloads
A.T.M Yusuf, Mohammad Mamun Ur Rashid*, Mohammed Mainul Hassan, Mohammed Aktar Sayeed, Mohammed Abdullah Jainul. In-Vitro Cytotoxic and Thrombolytic Potential of Pothos Scandens L. J Pharmacogn Phytochem 2013;2(1):193-198.