Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 4 (2013)
Sedative and Cytotoxic Properties of the leaf Extract of Desmodium paniculatum
Mohammad Mamun Ur Rashid1*, Humayun Kabir1, Mohammed Aktar Sayeed2, Rashedul Alam1, Mohammad Fazlul Kabir1
The present study was done to investigate the sedative and cytotoxic properties of methanol extract of Desmodium paniculatum Leaves. Sedative activity was evaluated by using hole cross, open field and thiopental sodium-induced sleeping time methods in swiss albino mice at 400 mg/kg body weight dose orally and the extract was evaluated by in-vitro brine shrimp lethality bioassay for investigating cytotoxic activity. The extract decreased the locomotor activity of mice in hole cross, open field test and minimize the onset of sleep and maximized the duration of sleeping time significantly (p<0.05) when administered with thiopental sodium. Moreover the extract showed remarkable cytotoxic activity, LC50 value of the extract was 50.01Âµg/ml which was compared with the standard drug vincristine sulfate as a positive control. In conclusion, the methanol extract of Desmodium paniculatum contains significant sedative and cytotoxic activity.
Pages: 63-67 | 2280 Views 283 Downloads
Mohammad Mamun Ur Rashid1*, Humayun Kabir1, Mohammed Aktar Sayeed2, Rashedul Alam1, Mohammad Fazlul Kabir1. Sedative and Cytotoxic Properties of the leaf Extract of Desmodium paniculatum. J Pharmacogn Phytochem 2013;2(4):63-67.