Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 5 (2014)
Evaluation of anti diarrheal potential of Moringa oleifera (Lam.) leaves
Ankita Misra, Sharad Srivastava, Manjoosha Srivastava
The objective of present study was to evaluate in vivo anti-diarrheal potential of Moringa oleifera leaves. Sample was analyzed for quantative estimation of phytochemicals and anti-diarrheal activity of ethanol extract, at 150 and 300 mg/kg body weight (b.w) was investigated using castor oil induced model. Study reveals that protein was maximum in leaves (23.35%) followed by fiber, starch, oil, sugar, alkaloid, tannin, flavanoid and phenolic. At dosages of 150 and 300 mg/kg b.w extract showed significant (p<0.01) activity, as compared to control. In course of observation for 4 hr, oral dose of 300mg/kg b.w showed remarkable dose dependent delay in onset of copious diarrhoea, decrease in the frequency of purging, weight of wet stools, weight of total stool and percentage protection. Study, thus signifies the potential clinical effect of extract in disease and needs to be extended further for activity guided extraction/isolation of the active chemical moiety.
Pages: 43-46 | 1815 Views 75 Downloads
Ankita Misra, Sharad Srivastava, Manjoosha Srivastava. Evaluation of anti diarrheal potential of Moringa oleifera (Lam.) leaves. J Pharmacogn Phytochem 2014;2(5):43-46.