Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 5 (2014)
Analgesic and neuropharmacological activities of methanolic leaf extract of Clitoria ternatea Linn.
Shammy Sarwar, Md. Rashidur Rahman, Kamrun Nahar, Muhammad Ashikur Rahman
The present study was carried out on methanolic extract of Clitoria ternatea Linn. for pharmacological investigations. In this study, analgesic activities of the methanolic extract of Clitoria ternatea Linn. leaves were examined at the doses of 200 mg/kg and 400 mg/kg of body weight on mice. The analgesic activities were investigated using acetic acid induced writhing test. The plant extractâ€™s Central Nervous System (CNS) depressant activity was evaluated by using hole cross and open field tests. Acetic acid induced writhing test revealed that the extract at the lower dose inhibited 82.67% and at the higher dose produced a maximum of 87.87% inhibition of writhing that is comparable to the reference drug Diclofenac Sodium. The results of CNS depressant activity showed that the extract decreased the dose dependent motor activity and exploratory behavior of mice in hole cross and open field test. The number of field crossed in open field test and hole crossed in hole cross test decreased as time approached.
Pages: 110-114 | 2176 Views 266 Downloads
Shammy Sarwar, Md. Rashidur Rahman, Kamrun Nahar, Muhammad Ashikur Rahman. Analgesic and neuropharmacological activities of methanolic leaf extract of Clitoria ternatea Linn.. J Pharmacogn Phytochem 2014;2(5):110-114.