Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 6 (2014)
Investigation of anticonvulsant activity of Vanda roxburghii
Dilnawaz Pathan, Shirishkumar Ambavade
The aim of the study was to investigate anticonvulsant effect of alcoholic extract of roots of Vanda roxburghii on electrically and chemically induced seizures. Methods:
The ethanolic extract of the roots of Vanda roxburghii (SVR) was studied for its anticonvulsant effect on maximal electroshock-induced seizures pentylenetetrazole, picrotoxin induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were observed. Results:
It has been observed in the present study that the ethanolic extract of roots of Vanda roxburghii (100 mg/kg) showed significant (P<0.05) increase in latency to clonic convulsions. Vanda roxburghii possess anticonvulsant activity against Pentylenetetrazole (PTZ), Maximal electroshock (M.E.S.) and Picrotoxin (PTX) induced convulsions in mice.
Pages: 95-99 | 2103 Views 212 Downloads
Dilnawaz Pathan, Shirishkumar Ambavade. Investigation of anticonvulsant activity of Vanda roxburghii. J Pharmacogn Phytochem 2014;2(6):95-99.