Journal of Pharmacognosy and Phytochemistry
Vol. 2, Issue 6 (2014)
Hypoglycemic, hypolipidemic and body weight effects of unripe pulp of Carica papaya using diabetic Albino rat model.
Ezekwe, Ahamefula Sunday., Elekwa, Ify., Osuocha, Kelechi Uzoma.
The present study was designed to evaluate some selected biochemical effects of unripe pulp of Carica papaya on alloxan induced diabetes in rats. Animals weighing (160-200 g) were divided into three (3) groups of 10 animals each; Group I (normal control), Group II (diabetic control) and Group III (test control). Diabetes was induced in albino rats by intraperitoneal injection of alloxan monohydrate at a single dose of 120 mg/kg body weight into groups II and III respectively. Animals in groups I and II received normal rat feeds while animals in group III were fed with unripe pulp of Carica papaya for a period of 28 days. Body weight and glucose levels were measured on days 0, 7, 14, 21, and day 28. It was observed in this study that there was a significant reduction of Glycated hemoglobin in the test group when compared with the induced control (diabetic rats) and normal control group (P<0.05). The unripe pulp of Carica papaya elicited significant (P<0.05) reduction of blood glucose, lipid profile parameters except high density lipoprotein cholesterol (HDL-C) which significantly increased (p<0.05). Result also showed significant (P<0.05) reduction in body weight. These action is believed to be due to the bioactive constituents of the plant. Unripe pulp of Carica papaya exhibits proven potentials in the parameters evaluated to become of important medicinal and pharmacological interest.
Pages: 109-114 | 1505 Views 38 Downloads
Ezekwe, Ahamefula Sunday., Elekwa, Ify., Osuocha, Kelechi Uzoma.. Hypoglycemic, hypolipidemic and body weight effects of unripe pulp of Carica papaya using diabetic Albino rat model.. J Pharmacogn Phytochem 2014;2(6):109-114.