Journal of Pharmacognosy and Phytochemistry
Vol. 3, Issue 1 (2014)
In vivo cytotoxic and In vitro antibacterial activities of Kaempferia galanga
Pritesh Ranjan Dash, Mahmuda Nasrin, Mohammad Shawkat Ali
Kaempferia galanga (Family: Zingiberaceae) has been used for the treatment of various skin disorders and widely used in the treatment of nematocide, larvicide, colera and various inflammatory disorders. The study was aimed to investigate the cytotoxic and antibacterial activity of different extracts of the rhizome and leaf of Kaempferia galanga. Cytotoxicity was determined against (Artemia salina) brine shrimp nauplii. The antibacterial activity was performed by disc diffusion method and determination of zone of inhibition of living microorganisms. In the brine shrimp lethality bioassay all the extracts showed moderate cytotoxic activity when compared with the standard drug vincristine sulphate. For example, LC50 value of the acetonic leaf extract was 4.78 Î¼g/ml while the LC50 of vincristine sulphate was 0.52 Î¼g/ml. All the natural products (400 Î¼g/disc) showed moderate antibacterial activity against both gram positive and gram negative bacteria as compared with the standard drug ciprofloxacin (5 Î¼g/disc).
Pages: 172-177 | 2250 Views 479 Downloads
Pritesh Ranjan Dash, Mahmuda Nasrin, Mohammad Shawkat Ali. In vivo cytotoxic and In vitro antibacterial activities of Kaempferia galanga. J Pharmacogn Phytochem 2014;3(1):172-177.