Journal of Pharmacognosy and Phytochemistry
Vol. 3, Issue 1 (2014)
Cytotoxic triterpenes from Diospyros kaki L. cv. costata (Ebenaceae)
Ola A. Sanad, Azza R. Abdel Monem, Zeinab A. Kandil
Four flavonoids (kaempferol-3-O-Î²-D-glucoside, quercetin-3-O-Î²-D-glucoside, kaempferol, and quercetin) and three triterpenes (ursolic acid, 3,19,24-trihydroxyurs-12-en and 3,19,24-trihydroxy-15-oxo-urs-12-en) were isolated from the ethyl acetate fraction of the alcoholic extract of Diospyros kaki L. cv. costata leaves cultivated in Egypt. The cytotoxic activity of 3,19,24-trihydroxyurs-12-en and 3,19,24-trihydroxy-15-oxo-urs-12-en was assessed on three human cell lines, cervical carcinoma (HELA), breast carcinoma (MCF7) and colon carcinoma (HCT116) cell lines using sulforhodamine-B assay. The two compounds exerted a moderate cytotoxic activity against the three tested cell lines comparing to doxorubicin as reference standard.
Pages: 231-234 | 1289 Views 30 Downloads
Ola A. Sanad, Azza R. Abdel Monem, Zeinab A. Kandil. Cytotoxic triterpenes from Diospyros kaki L. cv. costata (Ebenaceae). J Pharmacogn Phytochem 2014;3(1):231-234.