Journal of Pharmacognosy and Phytochemistry
Vol. 3, Issue 2 (2014)
Cytotoxic and antitumor effects of Tribulus terrestris L fruit methanolic extract
Divya Menon K, Sheema Dharmapal, Achuthan C R, Babu T D
Tribulus terrestris L. (Family: Zygophyllaceae) has been used extensively for various human ailments by different traditional systems of medicine including Ayurveda. Recently, the anti-proliferative effect of this plant against breast cancer cells was reported. In the present study, the cytotoxic and antitumour effects of the methanolic extract of T. terrestris fruits were analysed. On in vitro cytotoxicity analysis, the extract showed 50% inhibitory concentration (IC50) at 380 and 420 Âµg/ml, for Daltonâ€™s Lymphoma Ascites (DLA) and Ehrlichâ€™s Ascites Carcinoma (EAC) cells, respectively. The ascites tumor induced by EAC cells was found to be decreased considerably by the oral administration of the extract and the life span of the tumour bearing mice was enhanced to 31 and 45% by 100 and 250 mg/kg b. wt. extract, respectively.
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Divya Menon K, Sheema Dharmapal, Achuthan C R, Babu T D. Cytotoxic and antitumor effects of Tribulus terrestris L fruit methanolic extract. J Pharmacogn Phytochem 2014;3(2):01-04.