Author(s):

Shamshir khan, Bahar Ahmed, Habibullah Khalilullah, Mubashir H Masoodi

Abstract: Euphorbia hirta is a very popular herb amongst practitioners of traditional herbal medicine for its hypotensive, tonic, antipyretic, antiinflammatory, hypoglycemic and sedative activities. Moreover it is also used in different systems of medicine in the treatment of diarrhoea, bronchitis, skin diseases, fever, analgesic, gastrointestinal disorders, vomiting, wound healing, respiratory diseases and pulmonary disorders etc. Thus the aims of present study to assess the neuropharmacological activity of whole plant extract and characterized active constituents in rodent models of neurological disorders. The animals were treated with ethanolic extract, methanolic fraction and isolated compound; EH-1 (β-Stigmasterol glucoside), and anticonvulsant effect were evaluated against; Strychnine induced convulsion in mice; pentylenetetrazole (PTZ) induced seizure in mice; and maximal electroshock induced seizure in mice. The motor co-ordination, nootropic and anxiolytic activity was assessed in rats using rota rod and cook’s pole climb apparatus and elevated plus maze respectively. The methanolic fraction has shown significant anticonvulsant, locomotor, nootropic and anxiolytic activity. However the isolated compound has not shown significant neuropharmacological activity. In conclusion the methanolic fraction and ethanolic extract (150 mg/kg p.o.) have shown significant neuropharmacological activities that could be the abundance of antioxidant constituents viz glycoside, flavonoids and phenolic compounds however isolated compound β-Stigmasterol glucoside did not shown significant effect.

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