Journal of Pharmacognosy and Phytochemistry
Vol. 3, Issue 3 (2014)
Anti-Oxidant and hepatoprotective activities of ethanolic root extract of Bauhinia variegata Linn
P. Meena Prabha V. Kamalakkannan, Dr. K. S. G. Arul kumaran, Dr. R. Sambathkumar
To study the hepatoprotective activity of BVEE. In-vitro Antioxidant Studies was carried out by using Nitric oxide scavenging activity method and DPPH radical scavenging activity method. Albino wistar rats of either sex weighing 150-200g were divided into five groups. Liver injury was produced by CCL4 1 ml/kg/d dissolved in olive oil (1:1) orally. Silymarin (100mg/kg) orally was used as standard drug. Test groups received BVEE in the doses of 200,400 mg/kg/day orally along with CCl4. Treatment was given to all the groups daily for 5 days. The hepatoprotective effect of BVEE was evaluated by assessment of biochemical parameters AST, ALT, ALP and Level of total protein Histopathological examination of the liver was also done. BVEE (200mg/kg and 400 mg/kg) exhibited highly significant reduction (p<0.01) in AST, ALT, ALP, GGT and total protein. Histopathological examination of the liver suggested hepatoprotective effect of the extract by decreasing the extent of centrilobular necrosis, fatty changes and congestion of sinusoids when compared to carbon tetrachloride group. BVEE showed significant dose dependent protection against CCL4 induced liver injury in rats.
Pages: 92-98 | 1556 Views 35 Downloads
P. Meena Prabha V. Kamalakkannan, Dr. K. S. G. Arul kumaran, Dr. R. Sambathkumar. Anti-Oxidant and hepatoprotective activities of ethanolic root extract of Bauhinia variegata Linn. J Pharmacogn Phytochem 2014;3(3):92-98.