Author(s):

Phani Kumar K, Annapurna A, Ramya G, Sheba D, Gopal Krishna Ch, lakshmi Sudeepthi NL

Abstract: Hibiscus rosa sinensis L.(malvaceae) flower extracts were selected and evaluated for gastroprotective activity by using Pylorus ligation, aspirin induced and ethanol induced ulceritis in rats. Phytochemical and pharmacological screening of extracts revealed the presence of flavonoids, alkaloids and tannins and significant (p <0.05) gastro protective action in all the gastric ulcer induced models compared to reference standard. Aqueous extract 250 mg/kg offered more percentage of protection, 84.17%, 77.12% and 76.8% in pylorus ligation, aspirin induced and ethanol induced ulcer models, respectively. The protective effect observed is attributed to its effect on mucus production and free radical scavenging effect of flavonoids and tannins present in crude extract. Our study report the gastroprotective activity of flower extracts of Hibiscus rosa sinensis against experimentally induced gastric erosions in rats.

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