Author(s):

K. Dinesh, V. Sivakumar, B. Selvapriya, E. Deepika, A. Mohamed Sadiq

Abstract: The aim of the present study was to evaluate the hepatoprotective effect of poly herbal formulations contains some Indian medicinal plant on paracetamol induced hepatic damaged experimental animals. rnMaterials and methods: Paracetamol (3 g/kg, p.o) was administered a single dose to induce hepatotoxicity. F-I, F-II and F-III(200 mg/kg, p.o) and silymarin (25 mg/kg, P.o) were administered once daily for 8 days. The degree of hepatoprotection was measured using morphological parameters of changing in colour and weight of liver are determined. Biochemical parameters in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), bilirubin and plasma protein. The histopathological parameters of histological changes in the liver architecture like architecture of hepatic lobules, swelling of liver cell, fatty changes, focal necrosis, inflammatory cell infiltration around portal areas, kupffer cell hyperplasia etc. and the functional parameters of pentobarbitone sleeping time was used as a functional parameter. rnResults: F-I, F-II and F-IIIpretreatment showed normal morphological parameters signs and significant effect of serum enzymes, total protein and bilirubin levels. Highly significantly protect the hepatic damage and morphological and histopathological changes and less pentobarbitone sleeping time were observed in all the three poly herbal formulationstreated rats. Conclusion: The result of this study strongly indicated that the entire three poly herbal formulations have got a hepatoprotective action against paracetamol induced hepatic damage in experimental animals.

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