Author(s):

Jayavelu Sathya, Mabel Parimala and Francis Gricilda Shoba

Abstract: The aim of the study was to evaluate the α-amylase and α-glucosidase inhibitory potential of Citrullus lanatus seed methanol extract in regulating postprandial hyperglycemia. In vitro α-amylase and α-glucosidase inhibition assay was performed by standard protocols using the extract at ten different concentrations. The methanolic extract of C. lanatus exhibited the best inhibitory activity against α-glucosidase with IC50 values of 54.44 μg/ml and a mild inhibitory activity against α-amylase with IC50 values of 76.68 μg/ml. Hence, from the present study, we conclude that C. lanatus seed methanol extract is a potent glucosidase inhibitor which can be used in the management of type 2 diabetes.

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