Journal of Pharmacognosy and Phytochemistry
Vol. 3, Issue 5 (2015)
Identification of glucosidases inhibitory potential from Citrullus lanatus seed extract
Jayavelu Sathya, Mabel Parimala and Francis Gricilda Shoba
The aim of the study was to evaluate the Î±-amylase and Î±-glucosidase inhibitory potential of Citrullus lanatus seed methanol extract in regulating postprandial hyperglycemia. In vitro Î±-amylase and Î±-glucosidase inhibition assay was performed by standard protocols using the extract at ten different concentrations. The methanolic extract of C. lanatus exhibited the best inhibitory activity against Î±-glucosidase with IC50 values of 54.44 Î¼g/ml and a mild inhibitory activity against Î±-amylase with IC50 values of 76.68 Î¼g/ml. Hence, from the present study, we conclude that C. lanatus seed methanol extract is a potent glucosidase inhibitor which can be used in the management of type 2 diabetes.
Pages: 12-14 | 2462 Views 322 Downloads
Jayavelu Sathya, Mabel Parimala and Francis Gricilda Shoba. Identification of glucosidases inhibitory potential from Citrullus lanatus seed extract. J Pharmacogn Phytochem 2015;3(5):12-14.