Journal of Pharmacognosy and Phytochemistry
Vol. 3, Issue 5 (2015)
CNS Depressant, Analgesic and Anti-inflammatory Activities of Methanolic Seed Extract of Calamus rotang Linn. Fruits in rat
Farhana Alam Ripa, Pritesh Ranjan Dash and Md. Omar Faruk
This study was aimed to investigate CNS depressant, analgesic and anti-inflammatory activities of methanolic seed extract of Calamus rotang (MCRS)in rats. Hole cross and open field tests for CNS depressant effect, acetic acid-induced writhing and formalin induced pain methods for analgesic and carrageenan-induced paw edema was performed to evaluate anti-inflammatory effect of the doses of 250 and 500 mg/kg b.w. respectively. In hole cross and open field tests, maximum suppression of locomotor activity were 81.42% and 86.61% with the higher dose (500 mg/kg) of extract, whereas for the standard drug diazepam (1 mg/kg) inhibition rate were 87.14% and 91.86% respectively. MCRS at the dose of 500 mg/kg exhibited maximum 51.27% inhibition against acetic acid-induced pain while indomethacin (10 mg/kg) displayed 58.86% inhibition. In formalin-induced test, 68.47% inhibition was produced by MCRS (500 mg/kg) and indomethacin produced 70.72% inhibition. In anti-inflammatory activity, the extract showed a significant (p<0.01) inhibition of paw edema after 30 min to 240 min compare to indomethacin. MCRS significantly (P<0.01) showed the above mentioned pharmacological effects in a dose dependent manner.
Pages: 121-125 | 1537 Views 109 Downloads
Farhana Alam Ripa, Pritesh Ranjan Dash and Md. Omar Faruk. CNS Depressant, Analgesic and Anti-inflammatory Activities of Methanolic Seed Extract of Calamus rotang Linn. Fruits in rat. J Pharmacogn Phytochem 2015;3(5):121-125.