Author(s):

Raad A Kaskoos, Anoosh Bashir Hagop, Abbas Mohamed Faraj, Javed Ahamad

Abstract: Antioxidants reduce the oxidative stress in cells and are therefore useful in the treatment of many human diseases, including cancer, cardiovascular diseases, diabetes and inflammatory diseases. The current paper evaluates the antioxidant potential of Gymnema sylvestre (leaves), Enicostemma littorale (aerial parts), Momordica charantia (fruits) extracts and their composite extract. The present study resulted a potent antioxidant composite extract with IC50 of 45 μg/ml. The individual plant extracts shows moderate antioxidant activity. Combining of plants resulted enhanced antioxidant activity, thus the efficacy of composite extract was found compared with standard synthetic antioxidant compounds (BHA and Vitamin C). The current study leads in a development of herbal composite extract from widely reported herbal drugs Gymnema sylvestre, Enicostemma littorale and Momordica charantia for the effective antioxidant agent. The developed composite extract can be used as natural antioxidant that is side effect-free alternative to synthetic antioxidants in the food processing industry and for use in preventive medicine.

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