Author(s):

Gunji Venkateswarlu, T. Swarupa Rani, M. Vani, P.A.J. Vineela

Abstract: The aim of the present study is to evaluate the effect of in-vitro anticancer activity of the petroleum ether extract of Cynodon dactylon against HEP-2 laryngeal, HELA cervical and MCF-7 breast cancer cell lines and it was compared with normal, Vero cell line using MTT assay showed a percentage of cell viability of 97% at 0.078 mg/ml which decrease with increase in concentration of extract. Anticancer activity of petroleum ether extract of Cynodon dactylon on HEP-2, HELA and MCF-7 cancer cell lines showed potent cytotoxic activity. The inhibition percentage with regard to cytotoxicity was found to be 93.5%, 88.5% and 79.2% at 10 mg/ml, which was comparable to the control Cyclophosphamide that showed a cytotoxicity of 96%, 92% and 83%. Therefore the minimum effective concentration of petroleum ether extract of Cynodon dactylon was non-toxic to Vero cells but toxic to HEP-2, HELA and MCF-7 cells(Ic50) was recorded at a concentration of 0.156 mg/ml 0.625 mg/ml of petroleum ether extract of Cynodon dactylon. Among these three cell lines Cynodon dactylon shows more activity in HEP-2 laryngeal cell line.

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