• Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 4, Issue 2 (2015)

Role of herbal bioenhancers (Piperine and Curcumin) on the oral bioavailability of Tamoxifen using experimental rats

Author(s):

V Kumar, Vineet Mittal and Pawan Jalwal

Abstract:
Tamoxifen is an anticancer drug which has very low oral bioavailability. It has been reported in the literature that the various P-gp and CYP3A4 enzyme inhibitors were co administered with drug to enhance their oral bioavailability. In the present report, the effect on the bioavailability of tamoxifen when co-administerd with herbal bioenhancers such as curcumin and piperine has been studied in experimental animals. The various pharmacokinetic parameters from different blood samples were determined using HPLC. It has been found that the co administration of selected bioenhancers significantly enhanced the oral bioavailability of tamoxifen.

Pages: 133-136  |  2100 Views  397 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
V Kumar, Vineet Mittal and Pawan Jalwal. Role of herbal bioenhancers (Piperine and Curcumin) on the oral bioavailability of Tamoxifen using experimental rats. J Pharmacogn Phytochem 2015;4(2):133-136.

Call for book chapter