Author(s):

Alisha Pereira, Rashmi Mallya

Abstract: Photoprotectives in skin-care is essential to prevent oxidative stress induced by long term exposure to UV. Phyllanthus emblica fruit extract contains polyphenols that are potent antioxidants. But polyphenols have limited penetration into skin therefore its topical use, as a photoprotectant, is ineffective. This study aims to develop a phospholipid complex of amla extract that enhances the delivery of polyphenols into the skin. The amla extract phospholipid developed, had an entrapment efficiency of 94.03±0.10 %. The characterization studies showed that constituents of amla extract successfully formed a complex with phospholipids. The complex was incorporated into a cream formulation, which was found to be stable. The ex-vivo diffusion studies of cream showed that administration of the amla extract via phospholipid complexes gave better skin retention compared to the conventional cream. Thus, phospholipid complex of amla extract gave a prolonged antioxidant effect compared to the conventional cream.

Pages: 232-240  |  3427 Views  1009 Downloads

Download (522KB)