Author(s):

Ikram Mohamed Eltayesb Elsiddig, Abdel Khalig Muddather, Hiba Abdel Rahman Ali, Saad Mohamed Hussein Ayoub

Abstract: Anogeissus leiocarpus plant is widely used in African and Sudanese traditional medicine and is well known for its antimicrobial activities against many pathogenic microorganisms for treating of many diseases. This study was carried out in vitro to compare the antibacterial and antifungal activities of alcoholic crude extracts and their petroleum ether, chloroform and ethyl acetate fractions of the leaf, stem and root of A. leiocarpusrngrowing in Sudan against five standards bacteria, Staphylococcus aureus, Escherichia coli, Klebsiella aerogens, Pseudomonas aeruginosa, Salmonella typhi, and two standards fungi, Candida albicans and Aspergillus niger. The bioactive fractions were subjected to TLC and HPLC analysis. The results showed remarkable antibacterial and antifungal activities of A. leiocarpus against these seven tested microorganisms. A comparison of RP HPLC-DAD chromatogram of six bioactive fractions clearly represented the presence of different phenolic compounds.

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