Author(s):

Gayathri Gopalakrishnan, Bindu Rajeshwary Nair, Babu V

Abstract: Azima tetracantha Lam. (Family: Salvadoraceae, Common name: Needle bush) is distributed along the coastal areas of India. It is a spiny, evergreen shrub with a tendency to scramble. In the present study, the anti-cancer as well as cytotoxic properties of methanol leaf extract of Azima tetracantha was determined, in vitro, against the cancer cell line HeLa and Human peripheral Lymphocyte (HPL) respectively. MTT assay was used to determine cell viability and LDH leakage assay was used to determine the cell permeability in both HeLa and HPL cells. A dose dependant cell proliferation inhibitory activity was observed for the methanol extract (IC50= <100µg/ml) against HeLa. However, the extract remained less toxic to normal cells, HPL. Thus, the present study revealed that the methanolic extract of Azima tetracantha possess chemoprotective effect and can be used as a potent agent in treating cancer.

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