Mukesh B Chawda, Nitin A Mundhe, Venu Gopal Jonnalagadda, Kapil S Thakur, MK Vahalia, Shekhar S Shitut
The main intent of this study is to evaluate the antiulcer activity of PlantacidÂ® suspension on non-steroidal anti-inflammatory drugs (NSAIDâ€™s) -induced ulcers in the rat model.rnMethods:
24 Wistar Rats weighing around 180-200g were fasted for 12 hours before the study and arbitrarily divided into 4 groups of 6 animals each. The 4 groups were: Vehicle (1 ml/kg, p.o), indomethacin (100 mg/kg, p.o), PlantacidÂ® suspension (2.7 ml/kg, p.o), and Ranitidine (100 mg/kg, p.o) groups respectively. The treatment was given 60 minutes before the administration of indomethacin. Effect of PlantacidÂ® suspension was studied by calculating the ulcer score, total number of ulcers, ulcer index and percentage inhibition. The results showing p values <0.05 were considered significant and all values are expressed as mean Â± S.E.M.
Results: Significant decrease in ulcer score (p<0.05), total number of ulcers (p<0.0001), ulcer index (p<0.001), and % inhibition of ulcer was reduced by 82.06%, and 90.04 % in PlantacidÂ® suspension and Ranitidine treated groups respectively, as compared to the indomethacin group.
Conclusion: The results indicate that PlantacidÂ® suspension has showed antiulcer activity in experimental animals and corroborates Ayurvedic use of PlantacidÂ® suspension in gastric ulcers.rn
Mukesh B Chawda, Nitin A Mundhe, Venu Gopal Jonnalagadda, Kapil S Thakur, MK Vahalia, Shekhar S Shitut. Anti-Ulcer activity of PlantacidÂ® suspension in Wistar rats: A pilot study. J Pharmacogn Phytochem 2015;4(4):175-178.