Journal of Pharmacognosy and Phytochemistry
Vol. 4, Issue 4 (2015)
In vivo anticancer potential of root tubers of Asparagus gonoclados Baker. against dalton ascitic lymphoma (DAL)
Tijare RD, Beknal AK, Mahoorkar N
Herbals are valuable due to their medicinal properties and effectiveness in various diseases where allopathic drugs are less active such as psoriasis, hepatitis etc. In present study root tubers of the Asparagus gonoclados Baker were used as a drug for screening of the in vivo anticancer activity by using the DAL cell model. rnThe selected drug was evaluated for the pharmacognostical and phytochemical screening including antineoplastic activity. Pharmacognostical studies includes TS, maceration and powder drug analysis which gave comprehensive results which helps in proper identification. Drug had also under gone some standardization process which helps in development of some standards such as ash value (0.398% w/w), alcohol soluble extractives (41.09% w/w), water soluble extractives (31.26% w/w), moisture content and, Florescent analysis etc., for standardization rnIn present study selected drug has been screened for anticancer property by using DAL cells, where cancer was induced to all animals which are groped as normal, positive control, standard and some test groups. Study showed the comprehensive results for anticancer activity. Alcohol extract in high dose level showed the significant results in comparison to the disease group and normal with p value <0.001. Similarly aqueous extract showed the same response, henceforth, it gave a conclusion of dose dependant activity of the selected drug.
Pages: 263-266 | 1848 Views 157 Downloads
Tijare RD, Beknal AK, Mahoorkar N. In vivo anticancer potential of root tubers of Asparagus gonoclados Baker. against dalton ascitic lymphoma (DAL). J Pharmacogn Phytochem 2015;4(4):263-266.