Author(s):

Mohammad Shahriar, Nishat Zareen Khair, Zara Sheikh, Sayeeda Fahmee Chowdhury, Md. Kamruzzaman, Md. Shawkatul Islam Bakhtiar, Sharmin Jahan Chisty

Abstract: Annona reticulata (Annonaceae) is known as atafol in Bangla and custard apple in English is an important medicinal plant. It has been used traditionally in diarrhea, dysentery, cold, as abortifacient, insecticidal drug etc. In this present study, the leaf extracts of Annona reticulata were subjected to evaluation of the thrombolytic activity was assessed by using human erythrocyte and the results were compared with standard streptokinase (SK). The chloroform extract showed 36.82% clot lysis as compared to 93.79% clot lysis produced by standard streptokinase. The leaf extracts of Annona reticulata were subjected to evaluation of the membrane stabilizing activity by using human erythrocyte and the results were compared with standard anti-inflammatory drug, acetyl salicylic acid (ASA). In vitro membrane stabilizing activity for hypotonic solution induced haemolysis, the chloroform extract inhibited 75.15% haemolysis of RBCs as compared to 72.99% produced by acetyl salicylic acid (ASA) and during heat induced condition different organicrnsoluble materials of Annona reticulata  demonstrated methanol, ethanol and chloroform extract showed 68.81%, 72.06% and 78.17% inhibition of RBC hemolysis respectively whereas standard acetylsalicylic acid showed 70.87% inhibition of RBC haemolysis.

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