Journal of Pharmacognosy and Phytochemistry
Vol. 5, Issue 4 (2016)
Review on- Herbosomes, A new arena for drug delivery
Nazneen Dewan, Debaprotim Dasgupta, Suravi Pandit and Prince Ahmed
The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compounds. Herbosomes are recently introduced the herbal formulations that have better bioavailability and actions than the conventional botanical extracts. Herbosomes technology is one of such systems that incorporate phospholipids into standardized active ingredients of herbal extracts, thus effectively enhancing the bioavailability of water soluble bioactive constituents of phytomedicines such as flavonoids, phenolics and hydrophilic compounds. There are many herbal extracts having excellent bioactivity in vitro
but less in vivo
because of their poor lipid solubility and improper size of the molecule or both, which result in poor absorption and bioavailability of herbal extract or constituents from herbal extract and they destroyed in the gastric fluids when taken orally. Recent advances in natural products chemistry and phytomedicine research has been aimed at novel lipid based drug delivery systems. Since they have improved pharmacological and pharmacokinetic parameters. Herbosomes absorption in GIT is greater resulting in increased plasma level than individual component. Herbosome act as bridge between novel delivery system and conventional delivery system. Phospholipids molecule acting as vital carrier made up of water soluble head and two fat soluble tails, due to this nature they possess dual solubility and thus acting as an effective emulsifier.
Pages: 104-108 | 2898 Views 584 Downloads
Nazneen Dewan, Debaprotim Dasgupta, Suravi Pandit and Prince Ahmed. Review on- Herbosomes, A new arena for drug delivery. J Pharmacogn Phytochem 2016;5(4):104-108.