Author(s):

Md. Anamul Haque, Rajashree Chowdhury, Banolata Sikder, Shahin Mahmud, Hasib-Al-Mahfuj, Md. Raihan Sarker and ASM Monjur-Al- Hossain

Abstract: Scurrula parasitica (Linn.) has been used as traditional medicine against various diseases. Aim of the study was to evaluate analgesic, anti-inflammatory and CNS-depressant effects of methanol (MSPL), dichloromethane (DSPL), chloroform (CSPL) and aqueous (ASPL) extracts of S. parasitica leaves. Acetic acid-induced writhing and heat-induced tail immersion tests were used to evaluate analgesic effect while carrageenan-induced paw edema model was applied to find out anti-inflammatory potential at100 and 200 mg/kg, b.w dose. The CNS-depressant effect of the extracts were evaluated by using open field and hole cross tests. All the extracts significantly (Pb<0.01, Pa<0.001) showed analgesic, anti-inflammatory and CNS depressant effects as dose dependant manner. Aqueous fraction showed maximum analgesic effect (74.54% inhibition of abdominal writhing and 90.78% elongation of tail withdrawal time) at 200mg/kg dose. The highest anti-inflammatory potential (92.10% inhibition of paw edema volume) was showed by the dichloromethane fraction at 200mg/kg dose. On the other hand, chloroform extract proved to have significant (96.16% and 95.01% inhibition of locomotion in open field and in hole cross test respectively) CNS-depressant activity after 120 min of oral administration of the extract at 200mg/kg dose. In conclusion, the methanol, dichloromethane, chloroform and aqueous extracts of the S. parasitica leaves possess marked analgesic, anti-inflammatory and CNS- depressant effects.

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