Journal of Pharmacognosy and Phytochemistry
Vol. 5, Issue 5 (2016)
Assessment of neuropharmacological activities of Borassus flabellifer L. roots
Md. Abdullah Aziz, Kishore Kumar Sarkar, Mst. Irin Akter, AK Lutful Kabir and Debendra Nath Roy
In the present study the methanolic extract of Borassus flabellifer
L. (MBF) was evaluated for the safety along with neuropharmacological activity by using OECD guidelines, y-maze, elevated plus-maze and open field test respectively. Mortality, sign of any toxicity or behavioral changes were not noticed up to the dose as high as 4000mg/kg. Moreover, in y-maze test, MBF 200 mg/kg and MBF 400 mg/kg exhibited anti-depressive and depressive activities. Again, every extract including both lower and higher doses elicited depressive, anti- depressive and anxiolytic activities in elevated plus maze test. Later, in open field test, significant (p
.control) CNS depressive activities were found by both MBF 200 mg/kg and MBF 400 mg/kg. The results obtained in the present study demonstrated that MBF can be the possible sources of CNS depressant, anti- depressant and anxiolytic agents. But further investigation is needed for the identification of the active compounds as well as confirmation of their activities.
Pages: 252-256 | 1334 Views 124 Downloads
Md. Abdullah Aziz, Kishore Kumar Sarkar, Mst. Irin Akter, AK Lutful Kabir and Debendra Nath Roy. Assessment of neuropharmacological activities of Borassus flabellifer L. roots. J Pharmacogn Phytochem 2016;5(5):252-256.