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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 5, Issue 6 (2016)

Phytochemical analysis and antioxidant, analgesic and thrombolytic activity investigation of methanol extract of Pisum sativum seed

Author(s):

Amer Khorshed Alam and Chand Sultana Khatun

Abstract:
The aim of the present study was to investigate the presence of major phytochemicals and the analgesic, antioxidant and thrombolytic effects of methanol extract of the seeds of a plant Pisum sativum. Phytochemical analysis of the extract of Pisum sativum seeds indicated the presence of Glycoside, Alkaloid, Flavonoids, Saponin and Tannin types of compounds. Significant analgesic effect was monitored (p<0.05) as the oral extract dose of 500 mg/kg showed 42.75% inhibition of writhing movements compared to standard drug Diclofenac which inhibited 74.20% writhing movement. Also in present study the methanol extract of Pisum sativum seeds have mild antioxidant activity. The IC50 of the extraction was 489.25 µg/ml, whereas IC50 of reference anti-oxidative agent Ascorbic acid was 16.28 µg/ml. Pisum sativum extracts showed thrombolytic activity of (18.25 ± 0.04%) comparing with standard Streptokinase (66.98 ± 0.11%).

Pages: 366-370  |  1364 Views  86 Downloads

How to cite this article:
Amer Khorshed Alam and Chand Sultana Khatun. Phytochemical analysis and antioxidant, analgesic and thrombolytic activity investigation of methanol extract of Pisum sativum seed. J Pharmacogn Phytochem 2016;5(6):366-370.