Journal of Pharmacognosy and Phytochemistry
Vol. 6, Issue 2 (2017)
Ameliorative effect of Urtica dioica root extract on CdCl2- induced hepatotoxicity in rats
Maissa T Shawagfeh
Different parts of Urtica dioica
are known for its antioxidant compounds having various applications in the health and nutritional products. The aim of this study was to elucidate the antioxidant properties of dried root extracts against CdCl2
induced acute liver damage by monitoring the hepatic biochemical markers at dose 250 mg/kg/day for 4 days and were subsequently exposed to a single dose Cd (4 mg/kg) intraperitoneally (i.p.) 12 hours after the last extract/ vehicle treatment.CdCl2
induced hepatotoxicity was evident from the increased activities of serum hepatic marker enzymes and total bilirubin along with reduction in total protein and albumin levels. Administration of Urtica dioica
root extract at dose 250 mg/kg daily significantly reversed the enzyme activities and total bilirubin to their near normal and T. protein and albumin were increased significantly back to normal.
Pages: 130-133 | 1350 Views 148 Downloads
Maissa T Shawagfeh. Ameliorative effect of Urtica dioica root extract on CdCl2- induced hepatotoxicity in rats. J Pharmacogn Phytochem 2017;6(2):130-133.