Farhina Rahman Laboni, Tasmin Sultana, Samia Kamal, Samira Karim, Sajan Das, Md. Harun-Or-Rashid and Mohammad Shahriar
In this present study, the leaf extracts of Coccinia grandis
L., were subjected to evaluation of the phytochemical screenings, thrombolytic, membrane stabilizing, antioxidant, antimicrobial and cytotoxic activity. The ethanol extract showed 43.71% clot lysis as compared to 65.16% clot lysis produced by standard streptokinase. In vitro
membrane stabilizing activity for hypotonic solution and heat induced haemolysis the ethanol extract inhibited 79.53% and 90.30% haemolysis of RBCs as compared to 71.90% and 77.20% produced by acetyl salicylic acid respectively. In vitro
antioxidant activity revealed that the ethanol extracts of C. grandis
exhibited significant antioxidant activity with IC50
value of 1.15 mg/ml in comparison with the standard 5.80 mg/ml. Leave extracts of Coccinia grandis
revealed moderate antimicrobial activity against some gram positive and gram negative microorganisms. Leave extracts showed strong inhibitory effect on brine shrimp lethality with LC50
at 24.20 Î¼g/ml.
Farhina Rahman Laboni, Tasmin Sultana, Samia Kamal, Samira Karim, Sajan Das, Md. Harun-Or-Rashid and Mohammad Shahriar. Biological investigations of the ethanol extract of the aerial part (leaf) of Coccinia grandis L. J Pharmacogn Phytochem 2017;6(2):134-138.