Author(s):

El-Sayed M El-Ghaly

Abstract: One monounsaturated fatty acid ester and three anthraquinones were isolated for the first time from the leaves of Asphodelus microcarpus and identified as oleic acid methyl ester (1), chrysophanol (2), 10-(chrysophanol-7-yl)-10-hydroxychrysophanol-9-anthrone (3) and asphodoside C (4). The compounds were identified on the basis of 1D and 2D NMR and MS analyses. The methanolic extract of A. microcarpus leaves demonstrated a higher antimicrobial activity against Staphylococcus aureus and Candida albicans with an MIC value of 78µg/ml. The methanolic extract showed also a moderate antiviral activity against HAV-10 virus and a highest cytotoxic activity against lung carcinoma cell line (A-549) with IC₅₀ value of 29.3µg/ml.

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