Journal of Pharmacognosy and Phytochemistry
Vol. 6, Issue 2 (2017)
Phytochemical and biological activities of Asphodelus microcarpus leaves
El-Sayed M El-Ghaly
One monounsaturated fatty acid ester and three anthraquinones were isolated for the first time from the leaves of Asphodelus microcarpus
and identified as oleic acid methyl ester (1), chrysophanol (2), 10-(chrysophanol-7-yl)-10-hydroxychrysophanol-9-anthrone (3) and asphodoside C (4). The compounds were identified on the basis of 1D and 2D NMR and MS analyses. The methanolic extract of A. microcarpus
leaves demonstrated a higher antimicrobial activity against Staphylococcus aureus
and Candida albicans
with an MIC value of 78Âµg/ml. The methanolic extract showed also a moderate antiviral activity against HAV-10 virus and a highest cytotoxic activity against lung carcinoma cell line (A-549) with IC50
value of 29.3Âµg/ml.
Pages: 259-264 | 1444 Views 151 Downloads
El-Sayed M El-Ghaly. Phytochemical and biological activities of Asphodelus microcarpus leaves. J Pharmacogn Phytochem 2017;6(2):259-264.