Considerable research on Pharmacognosy, Phytochemistry and Pharmacology and Clinical therapeutics has been carried out on Ayurvedic medicinal plants. This review article will take a closer look at the various pharmacological activities of Trianthema decandra by providing numerous potential evidences. It has been used whole range of chronic and difficult to treat diseases such as cancer, cardiovascular diseases, immune modulator, hepatoprotective, diabetes, rheumatism, anti-inflammatory and analgesic, antimicrobial. Most developing countries have relied and will continue to rely on traditional natural medicines due to the difference of high costs of modern allopathic medicine.