Medicinal plants are the gift of nature and play an important role as a part of our diet to maintain health. They also serve as a versatile weapon to combat against a number of diseases. Every civilization has its own experience and knowledge of therapeutic uses of plants. The belief and observations regarding traditionally used medicinal plants, increasing the interest of people to use them against urolithiasis. Urolithiasis is a common problem afflicted for many centuries with high recurrence. World population of about 12% suffers with urolithiasis. All over the world in different countries and cultures people use plants for the prevention and cure of kidney stone according to their ethnopharmacological information. These formulations are very effective that's why these are used for hundreds of years. This review covers the eighty (80) medicinal plants of most cited family Asteraceae against urolithiasis along with their historical antiurolithiatc background shared in well-known books of Dioscorides, Pliny the Elder, Al Razi and Ibn Sina. This information was extracted to compose antiurolithiatic plants with their parts and formulations used in 21 countries such as Algeria, America, Australia, China, India, Iran, Italy, Jordan, Jordan, Kyrgyzstan, Lebanon, Libya, Mexico, Morocco, Pakistan, Palestine, Philippine, Spain, Tunisia, Turkey and Uzbekistan. Scientifically proved pharmacological activities of the same part of plant have direct (litholytic) and in direct pharmacological effects like analgesic, anti-inflammatory, antioxidant, astringent, demulcent, diuretic, litholytic, lithotriptic, antiurolithiatic, antispasmodic, ACE inhibition and Phospholipase A2 inhibition also shared as a plausible mechanism of action. The route of administration is oral in all cases. Hopefully, this book will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery. This valuable ethnopharmacological information will provide the opportunities for the future research and development of new natural antiurolithiatic compounds.
Salman Ahmed, Muhammad Mohtasheemul Hasan and Zafar Alam Mahmood. Globally used antiurolithiatic plants of family Asteraceae: Historical background, mechanism of action, therapeutic spectrum, formulations with doses. J Pharmacogn Phytochem 2017;6(3):394-402.